DirectMeds vs BettermeRx: NAD+ Therapy Compared
DirectMeds starts at $99 first month (500mg) and offers injection, while BettermeRx starts at shown after free evaluation with injection, nasal spray & liposomal oral. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
DirectMeds
Save $100 first month — 500mg from $99, then $199. 250,000+ served. No subscription.
Visit DirectMeds →
BettermeRx
Three NAD+ formats — injection, nasal spray, and liposomal. Flat pricing, no hidden fees.
Visit BettermeRx →| Feature | DirectMeds | BettermeRx |
|---|---|---|
| Editorial score | 9.64 / 10 | 9.72 / 10 |
| Starting price | $99 first month (500mg) | Shown after free evaluation |
| Renewal / ongoing | $199 (500mg) / $249 (1000mg) | Flat pricing, no increases |
| Delivery formats | Injection | Injection, nasal spray & liposomal oral |
| Dose strengths | 500mg & 1000mg | Injection 500/1000mg; nasal 900mg |
| Shipping | Free 1–2 day | Free UPS/FedEx |
| Membership / fees | None — no subscription | None |
| Guarantee | Satisfaction guarantee | — |
| Best for | People who want exact upfront pricing and no forced subscription, reordering on their own schedule | People who want to choose between injection, nasal spray, or liposomal NAD+ with flat, no-surprise pricing |
Where DirectMeds stands out
- + Lower entry price — $99 first month (500mg)
- + Backed by a satisfaction guarantee
- + Pricing shown upfront, before you start intake
Where BettermeRx stands out
- + More delivery formats — injection, nasal spray & liposomal oral
- + Higher editorial score (9.72 vs 9.64)
Pros & cons, side by side
DirectMeds
Pros
- + $100 off first month on the 500mg plan
- + Exact pricing shown upfront for both 500mg and 1000mg
- + No forced subscription — reorder manually when you want
- + 1:1 medical support with provider review within 24 hours
- + Free 1–2 day shipping included
Cons
- − Injection-only — no nasal or oral option
- − 1000mg plan renews at $249/mo
BettermeRx
Pros
- + Widest format choice: injection, nasal spray, and liposomal oral
- + Flat, all-inclusive pricing with no hidden fees
- + Free UPS/FedEx shipping on every order
- + U.S. board-certified physician evaluation included
Cons
- − Your exact price is shown after a free online evaluation
- − Compounded NAD+ — not an FDA-approved finished product
The verdict: DirectMeds vs BettermeRx
In our editorial ranking, DirectMeds places higher (#2 vs #6), making it the default pick for most readers — it's best for people who want exact upfront pricing and no forced subscription, reordering on their own schedule. That said, BettermeRx is the stronger choice for people who want to choose between injection, nasal spray, or liposomal NAD+ with flat, no-surprise pricing. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.