DirectMeds vs Enhance MD: NAD+ Therapy Compared
DirectMeds starts at $99 first month (500mg) and offers injection, while Enhance MD starts at wafers $84/mo; injection $169/mo with injection + sublingual wafer. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
DirectMeds
Save $100 first month — 500mg from $99, then $199. 250,000+ served. No subscription.
Visit DirectMeds →
Enhance MD
Injections $169–$199/mo or needle-free sublingual wafers $84–$99/mo. Physician oversight included.
Visit Enhance MD →| Feature | DirectMeds | Enhance MD |
|---|---|---|
| Editorial score | 9.64 / 10 | 8.51 / 10 |
| Starting price | $99 first month (500mg) | Wafers $84/mo; injection $169/mo |
| Renewal / ongoing | $199 (500mg) / $249 (1000mg) | Wafers $84–$99; injection $169–$199 |
| Delivery formats | Injection | Injection + sublingual wafer |
| Dose strengths | 500mg & 1000mg | Per physician protocol |
| Shipping | Free 1–2 day | Included |
| Membership / fees | None — no subscription | None |
| Guarantee | Satisfaction guarantee | Refund if ineligible |
| Best for | People who want exact upfront pricing and no forced subscription, reordering on their own schedule | People weighing injectable NAD+ against a needle-free sublingual wafer with full price transparency |
Where DirectMeds stands out
- + Higher editorial score (9.64 vs 8.51)
Where Enhance MD stands out
- + Lower entry price — Wafers $84/mo; injection $169/mo
- + More delivery formats — injection + sublingual wafer
Pros & cons, side by side
DirectMeds
Pros
- + $100 off first month on the 500mg plan
- + Exact pricing shown upfront for both 500mg and 1000mg
- + No forced subscription — reorder manually when you want
- + 1:1 medical support with provider review within 24 hours
- + Free 1–2 day shipping included
Cons
- − Injection-only — no nasal or oral option
- − 1000mg plan renews at $249/mo
Enhance MD
Pros
- + Needle-free sublingual wafer alternative to injections
- + Full published pricing matrix by commitment length
- + Provider check-ins, messaging, and cellular health lab tracking included
- + Full refund if found ineligible
Cons
- − Lowest prices require a 12-month prepaid commitment
- − No nasal spray option
The verdict: DirectMeds vs Enhance MD
In our editorial ranking, DirectMeds places higher (#5 vs #13), making it the default pick for most readers — it's best for people who want exact upfront pricing and no forced subscription, reordering on their own schedule. That said, Enhance MD is the stronger choice for people weighing injectable NAD+ against a needle-free sublingual wafer with full price transparency. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.