DirectMeds vs Shed: NAD+ Therapy Compared
DirectMeds starts at $99 first month (500mg) and offers injection, while Shed starts at $144/mo nasal (20% off first month) with nasal spray, injection & oral tablets. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
DirectMeds
Save $100 first month — 500mg from $99, then $199. 250,000+ served. No subscription.
Visit DirectMeds →
Shed
20% off first month — three NAD+ formats: nasal from $144, injections & oral from $169. Coaching resources included.
Visit Shed →| Feature | DirectMeds | Shed |
|---|---|---|
| Editorial score | 9.64 / 10 | 8.94 / 10 |
| Starting price | $99 first month (500mg) | $144/mo nasal (20% off first month) |
| Renewal / ongoing | $199 (500mg) / $249 (1000mg) | $144 nasal / $169 injection & oral |
| Delivery formats | Injection | Nasal spray, injection & oral tablets |
| Dose strengths | 500mg & 1000mg | Provider-determined |
| Shipping | Free 1–2 day | To your door |
| Membership / fees | None — no subscription | None — 1:1 coaching is an optional add-on |
| Guarantee | Satisfaction guarantee | — |
| Best for | People who want exact upfront pricing and no forced subscription, reordering on their own schedule | People who want format choice plus built-in wellness coaching resources |
Where DirectMeds stands out
- + Lower entry price — $99 first month (500mg)
- + Backed by a satisfaction guarantee
- + Higher editorial score (9.64 vs 8.94)
Where Shed stands out
- + More delivery formats — nasal spray, injection & oral tablets
Pros & cons, side by side
DirectMeds
Pros
- + $100 off first month on the 500mg plan
- + Exact pricing shown upfront for both 500mg and 1000mg
- + No forced subscription — reorder manually when you want
- + 1:1 medical support with provider review within 24 hours
- + Free 1–2 day shipping included
Cons
- − Injection-only — no nasal or oral option
- − 1000mg plan renews at $249/mo
Shed
Pros
- + 20% off your first month
- + Three delivery formats: nasal spray, injection, and oral tablets
- + Health courses and community included
- + Strong 4.6-star Trustpilot rating
Cons
- − 1-on-1 coaching is a paid add-on
- − Cancellation requires completing at least two months
The verdict: DirectMeds vs Shed
In our editorial ranking, DirectMeds places higher (#5 vs #11), making it the default pick for most readers — it's best for people who want exact upfront pricing and no forced subscription, reordering on their own schedule. That said, Shed is the stronger choice for people who want format choice plus built-in wellness coaching resources. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.