How NAD+ Treatment Works, Step by Step

Online NAD+ treatment follows the same sequence at nearly every provider. Understanding it in advance mostly helps you notice where providers differ — because the differences are not in the steps, they are in the terms attached to each one.

Step 1 — Choose a provider

This is the decision that determines everything downstream: what you pay, how much medication you get, what ships with it, and how easily you can stop. Compare on published price and renewal rate, medication quantity, treatment format, whether shipping and supplies are included, subscription requirements and cancellation terms. Our provider comparison puts all of those side by side.

Step 2 — The online intake

A health questionnaire covering your medical history, current medications and supplements, allergies and what you want from treatment. It takes five to ten minutes. Answer it accurately and completely — the clinician's decision and your protocol are built entirely from it.

Step 3 — Provider consultation and review

A licensed clinician reviews your intake. Most providers run this asynchronously rather than as a video call. DirectMeds and CareBareRx both publish a 24-hour review window. Providers that emphasise personalization — Enhanced.com, RenuviaRX, RNK Health, Fridays — spend more of this stage tailoring your dose; providers with fixed 500 mg and 1,000 mg tiers are faster but less individualized.

If treatment is not appropriate for you, several providers remove the financial downside entirely: bmiMD refunds in full, Enhance MD refunds if you are found ineligible, Sprout Health does not charge, and Embody refunds if you are not eligible.

Step 4 — Prescription and delivery

A partner pharmacy compounds and packs your prescription, then ships it. Shipping is free at every provider that publishes a policy, typically 1–2 day or 2-day. Compounded NAD+ generally ships cold and needs refrigeration on arrival, so plan to be home on delivery day.

Step 5 — Your first dose

Injection plans arrive with the supplies needed to self-administer: needles, syringes, alcohol wipes and sharps disposal, plus written instructions. Nasal spray arrives ready to use. Follow the instructions supplied with your specific prescription — dose and frequency are set by your prescribing clinician, and we do not publish dosing guidance.

If the first administration does not go the way the leaflet described, that is exactly what the included messaging is for. He & She MD and ReadyRx both publish unlimited provider messaging.

Step 6 — Refills and ongoing care

On a subscription plan, refills ship automatically on your plan schedule. DirectMeds and Wellmedr instead let you reorder manually. Most providers include some ongoing clinical contact — messaging at minimum, and at RNK Health coaching and wellness check-ins folded into the subscription.

Typical timeline

Day 0

Complete the online intake — five to ten minutes.

Day 0–1

Clinician reviews and, if appropriate, prescribes.

Day 1–3

Pharmacy dispenses and ships, usually free 1–2 day delivery.

Day 2–5

Package arrives. Refrigerate as instructed.

Week 1

First doses. Any initial side effects tend to appear here.

Weeks 2–4

Routine settles; most reported changes begin in this window.

Ongoing

Refills on plan schedule, with messaging access between them.

Subscription and cancellation

The end of the process deserves as much attention as the start. Three patterns:

• ›No subscription. DirectMeds and Wellmedr let you reorder when you want. Nothing to cancel.
• ›Cancel anytime. Embody and Sprout Health both publish this, and Enhanced.com backs it with a 90-day money-back guarantee.
• ›Minimum terms.Shed requires two completed months. RNK Health does not refund once medication ships. Prepaid 12-month plans at He & She MD, bmiMD, Enhance MD and Telos trade flexibility for the lowest rate.

Pricing and plan terms last verified August 2026. Provider terms change often — always confirm the current price, renewal rate and cancellation policy on the provider's own site before enrolling. We may earn a commission from partner links on this page, which never affects our rankings — see our disclosure. This page is informational and is not medical advice.