Enhanced.com vs DirectMeds: NAD+ Therapy Compared
Enhanced.com starts at $139/mo (was $232) and offers injection, while DirectMeds starts at $99 first month (500mg) with injection. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 22 Providers Compared
- Results in 2–4 Weeks
Enhanced.com
NAD+Rx from $139/mo (was $232) — personalized, clinician-supervised NAD+ injections backed by a 90-day money-back guarantee, no questions asked. Free 1–2 day shipping.
Visit Enhanced.com →
DirectMeds
Save $100 first month — 500mg from $99, then $199. 250,000+ served. No subscription.
Visit DirectMeds →| Feature | Enhanced.com | DirectMeds |
|---|---|---|
| Editorial score | 9.90 / 10 | 9.64 / 10 |
| Starting price | $139/mo (was $232) | $99 first month (500mg) |
| Renewal / ongoing | $129–$149/mo by plan length | $199 (500mg) / $249 (1000mg) |
| Delivery formats | Injection | Injection |
| Dose strengths | Personalized clinician protocol | 500mg & 1000mg |
| Shipping | Free 1–2 day | Free 1–2 day |
| Membership / fees | None | None — no subscription |
| Guarantee | 90-day money-back guarantee | Satisfaction guarantee |
| Best for | Adults who want a personalized, clinician-supervised NAD+ protocol backed by a 90-day money-back guarantee | People who want exact upfront pricing and no forced subscription, reordering on their own schedule |
Where Enhanced.com stands out
- + Higher editorial score (9.90 vs 9.64)
Where DirectMeds stands out
- + Lower entry price — $99 first month (500mg)
Pros & cons, side by side
Enhanced.com
Pros
- + Special offer: $139/mo (save 37%), as low as $129/mo on the 6-month plan
- + 90-day money-back guarantee — no questions asked
- + Personalized treatment plans from certified medical professionals
- + Trusted by 20,000+ happy customers
- + Free shipping — arrives in 1–2 days
- + Prescribed and monitored by board-certified providers
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − Requires a clinician consultation before your protocol is issued
DirectMeds
Pros
- + $100 off first month on the 500mg plan
- + Exact pricing shown upfront for both 500mg and 1000mg
- + No forced subscription — reorder manually when you want
- + 1:1 medical support with provider review within 24 hours
- + Free 1–2 day shipping included
Cons
- − Injection-only — no nasal or oral option
- − 1000mg plan renews at $249/mo
The verdict: Enhanced.com vs DirectMeds
In our editorial ranking, Enhanced.com places higher (#2 vs #4), making it the default pick for most readers — it's best for adults who want a personalized, clinician-supervised NAD+ protocol backed by a 90-day money-back guarantee. That said, DirectMeds is the stronger choice for people who want exact upfront pricing and no forced subscription, reordering on their own schedule. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.