Enhance MD vs RXSpan: NAD+ Therapy Compared
Enhance MD starts at wafers $84/mo; injection $169/mo and offers injection + sublingual wafer, while RXSpan starts at ~$249 (recurring) with not disclosed. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 22 Providers Compared
- Results in 2–4 Weeks
Enhance MD
Injections or needle-free sublingual wafers. Physician oversight included.
Visit Enhance MD →RXSpan
NAD+ treatment starting at approximately $249. Online medical consultation included; recurring billing shown before checkout.
Visit RXSpan →| Feature | Enhance MD | RXSpan |
|---|---|---|
| Editorial score | 8.51 / 10 | 8.40 / 10 |
| Starting price | Wafers $84/mo; injection $169/mo | ~$249 (recurring) |
| Renewal / ongoing | Wafers $84–$99; injection $169–$199 | Recurring; shown before checkout |
| Delivery formats | Injection + sublingual wafer | Not disclosed |
| Dose strengths | Per physician protocol | Not disclosed |
| Shipping | Included | Not stated |
| Membership / fees | None | None |
| Guarantee | Refund if ineligible | — |
| Best for | People weighing injectable NAD+ against a needle-free sublingual wafer with full price transparency | People who want a physician-consulted NAD+ plan with clear recurring billing before checkout |
Where Enhance MD stands out
- + Lower entry price — Wafers $84/mo; injection $169/mo
- + More delivery formats — injection + sublingual wafer
- + Backed by a refund if ineligible
- + Higher editorial score (8.51 vs 8.40)
Where RXSpan stands out
RXSpan is closely matched with Enhance MD on the headline metrics — the deciding factors come down to delivery format and the specifics below.
Pros & cons, side by side
Enhance MD
Pros
- + Needle-free sublingual wafer alternative to injections
- + Full published pricing matrix by commitment length
- + Provider check-ins and unlimited messaging included
- + Full refund if found ineligible
Cons
- − Lowest prices require a 12-month prepaid commitment
- − No nasal spray option
RXSpan
Pros
- + Online medical consultation included
- + Recurring billing shown before checkout
- + Fully online process
Cons
- − Higher starting price than many competitors
- − Compounded NAD+ — not an FDA-approved finished product
The verdict: Enhance MD vs RXSpan
In our editorial ranking, Enhance MD places higher (#15 vs #21), making it the default pick for most readers — it's best for people weighing injectable NAD+ against a needle-free sublingual wafer with full price transparency. That said, RXSpan is the stronger choice for people who want a physician-consulted NAD+ plan with clear recurring billing before checkout. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.