System vs Enhance MD: NAD+ Therapy Compared
System starts at injection $89 · nasal $69 (first month) and offers injection + nasal spray, while Enhance MD starts at wafers $84/mo; injection $169/mo with injection + sublingual wafer. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 32 Providers Compared
System
NAD+ injections from $89 and nasal treatment from $69 for the first month. Injection and nasal pricing shown separately.
Visit System →
Enhance MD
Injections or needle-free sublingual wafers. Physician oversight included.
Visit Enhance MD →| Feature | System | Enhance MD |
|---|---|---|
| Editorial score | 9.82 / 10 | 8.80 / 10 |
| Starting price | Injection $89 · nasal $69 (first month) | Wafers $84/mo; injection $169/mo |
| Renewal / ongoing | Shown during intake | Wafers $84–$99; injection $169–$199 |
| Delivery formats | Injection + nasal spray | Injection + sublingual wafer |
| Dose strengths | Not disclosed | Per physician protocol |
| Shipping | Not stated | Included |
| Membership / fees | None | None |
| Guarantee | — | Refund if ineligible |
| Best for | People choosing between injectable and nasal NAD+ with separate, accessible first-month pricing | People weighing injectable NAD+ against a needle-free sublingual wafer with full price transparency |
Where System stands out
- + Higher editorial score (9.82 vs 8.80)
Where Enhance MD stands out
- + Lower entry price — Wafers $84/mo; injection $169/mo
- + Backed by a refund if ineligible
Pros & cons, side by side
System
Pros
- + Both injection and nasal NAD+ options
- + Accessible first-month pricing
- + Fully online process
Cons
- − Compounded NAD+ — not an FDA-approved finished product
- − Ongoing pricing shown during intake
Enhance MD
Pros
- + Needle-free sublingual wafer alternative to injections
- + Full published pricing matrix by commitment length
- + Provider check-ins and unlimited messaging included
- + Full refund if found ineligible
Cons
- − Lowest prices require a 12-month prepaid commitment
- − No nasal spray option
The verdict: System vs Enhance MD
In our editorial ranking, System places higher (#5 vs #17), making it the default pick for most readers — it's best for people choosing between injectable and nasal NAD+ with separate, accessible first-month pricing. That said, Enhance MD is the stronger choice for people weighing injectable NAD+ against a needle-free sublingual wafer with full price transparency. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.