He & She MD vs System: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while System starts at injection $89 · nasal $69 (first month) with injection + nasal spray. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 32 Providers Compared
He & She MD
The only major NAD+ provider that lets you pick your format — injection, cream, or nasal spray — without paying a cent more for the privilege.
Visit He & She MD →
System
NAD+ injections from $89 and nasal treatment from $69 for the first month. Injection and nasal pricing shown separately.
Visit System →| Feature | He & She MD | System |
|---|---|---|
| Editorial score | 9.92 / 10 | 9.82 / 10 |
| Starting price | $149/mo (12-month supply) | Injection $89 · nasal $69 (first month) |
| Renewal / ongoing | Flat $149/mo across every format | Shown during intake |
| Delivery formats | Injection, topical cream & nasal spray | Injection + nasal spray |
| Dose strengths | Supplied as a 12-month course | Not disclosed |
| Shipping | Free expedited | Not stated |
| Membership / fees | None — no membership cost | None |
| Guarantee | — | — |
| Best for | People who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost | People choosing between injectable and nasal NAD+ with separate, accessible first-month pricing |
Where He & She MD stands out
- + Higher editorial score (9.92 vs 9.82)
Where System stands out
- + Lower entry price — Injection $89 · nasal $69 (first month)
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — subcutaneous injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format, locked on a 12-month supply
- + No membership fee, no hidden costs, and HSA/FSA cards accepted
- + 5-minute intake quiz reviewed by a licensed U.S. physician or DO
- + Unlimited provider messaging for as long as you are on the program
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is locked on a 12-month supply ($1,788/yr)
System
Pros
- + Both injection and nasal NAD+ options
- + Accessible first-month pricing
- + Fully online process
Cons
- − Compounded NAD+ — not an FDA-approved finished product
- − Ongoing pricing shown during intake
The verdict: He & She MD vs System
In our editorial ranking, He & She MD places higher (#1 vs #5), making it the default pick for most readers — it's best for people who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost. That said, System is the stronger choice for people choosing between injectable and nasal NAD+ with separate, accessible first-month pricing. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.