He & She MD vs BettermeRx: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while BettermeRx starts at shown after free evaluation with injection & nasal spray. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 32 Providers Compared
He & She MD
The only major NAD+ provider that lets you pick your format — injection, cream, or nasal spray — without paying a cent more for the privilege.
Visit He & She MD →
BettermeRx
Two NAD+ formats — subcutaneous injection and nasal spray — across three dosing plans. Flat pricing, no hidden fees.
Visit BettermeRx →| Feature | He & She MD | BettermeRx |
|---|---|---|
| Editorial score | 9.92 / 10 | 9.90 / 10 |
| Starting price | $149/mo (12-month supply) | Shown after free evaluation |
| Renewal / ongoing | Flat $149/mo across every format | Flat pricing, no increases |
| Delivery formats | Injection, topical cream & nasal spray | Injection & nasal spray |
| Dose strengths | Supplied as a 12-month course | Injection 500/1000mg; nasal 900mg |
| Shipping | Free expedited | Free UPS/FedEx |
| Membership / fees | None — no membership cost | None |
| Guarantee | — | — |
| Best for | People who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost | People who want to choose between an injection and a needle-free nasal spray with flat, no-surprise pricing |
Where He & She MD stands out
- + Lower entry price — $149/mo (12-month supply)
- + Pricing shown upfront, before you start intake
- + Higher editorial score (9.92 vs 9.90)
Where BettermeRx stands out
BettermeRx is closely matched with He & She MD on the headline metrics — the deciding factors come down to delivery format and the specifics below.
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — subcutaneous injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format, locked on a 12-month supply
- + No membership fee, no hidden costs, and HSA/FSA cards accepted
- + 5-minute intake quiz reviewed by a licensed U.S. physician or DO
- + Unlimited provider messaging for as long as you are on the program
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is locked on a 12-month supply ($1,788/yr)
BettermeRx
Pros
- + Injection or needle-free nasal spray, across three dosing plans
- + Flat, all-inclusive pricing with no hidden fees
- + Free UPS/FedEx shipping on every order
- + U.S. board-certified physician evaluation included
Cons
- − Your exact price is shown after a free online evaluation
- − Compounded NAD+ — not an FDA-approved finished product
The verdict: He & She MD vs BettermeRx
In our editorial ranking, He & She MD places higher (#1 vs #2), making it the default pick for most readers — it's best for people who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost. That said, BettermeRx is the stronger choice for people who want to choose between an injection and a needle-free nasal spray with flat, no-surprise pricing. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.