He & She MD vs DirectMeds: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while DirectMeds starts at $99 first month (500mg) with injection. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 22 Providers Compared
- Results in 2–4 Weeks
He & She MD
Our #1 NAD+ pick — three formats (injection, cream, and nasal spray) at one flat $149/mo. No membership, no hidden fees, free shipping.
Visit He & She MD →
DirectMeds
Save $100 first month — 500mg from $99, then $199. 250,000+ served. No subscription.
Visit DirectMeds →| Feature | He & She MD | DirectMeds |
|---|---|---|
| Editorial score | 9.90 / 10 | 9.64 / 10 |
| Starting price | $149/mo (12-month supply) | $99 first month (500mg) |
| Renewal / ongoing | Flat $149/mo across every format | $199 (500mg) / $249 (1000mg) |
| Delivery formats | Injection, topical cream & nasal spray | Injection |
| Dose strengths | Supplied as a 12-month course | 500mg & 1000mg |
| Shipping | Free expedited | Free 1–2 day |
| Membership / fees | None — no membership cost | None — no subscription |
| Guarantee | — | Satisfaction guarantee |
| Best for | People who want a choice of injection, cream, or nasal spray at one flat, transparent price with included ongoing care | People who want exact upfront pricing and no forced subscription, reordering on their own schedule |
Where He & She MD stands out
- + More delivery formats — injection, topical cream & nasal spray
- + Higher editorial score (9.90 vs 9.64)
Where DirectMeds stands out
- + Lower entry price — $99 first month (500mg)
- + Backed by a satisfaction guarantee
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format
- + No membership cost and no hidden fees
- + Board-certified providers and FDA-regulated dispensing pharmacies
- + Unlimited provider messaging for ongoing care
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is tied to a 12-month supply commitment
DirectMeds
Pros
- + $100 off first month on the 500mg plan
- + Exact pricing shown upfront for both 500mg and 1000mg
- + No forced subscription — reorder manually when you want
- + 1:1 medical support with provider review within 24 hours
- + Free 1–2 day shipping included
Cons
- − Injection-only — no nasal or oral option
- − 1000mg plan renews at $249/mo
The verdict: He & She MD vs DirectMeds
In our editorial ranking, He & She MD places higher (#1 vs #4), making it the default pick for most readers — it's best for people who want a choice of injection, cream, or nasal spray at one flat, transparent price with included ongoing care. That said, DirectMeds is the stronger choice for people who want exact upfront pricing and no forced subscription, reordering on their own schedule. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.