He & She MD vs Enhance MD: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while Enhance MD starts at wafers $84/mo; injection $169/mo with injection + sublingual wafer. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 22 Providers Compared
- Results in 2–4 Weeks
He & She MD
Our #1 NAD+ pick — three formats (injection, cream, and nasal spray) at one flat $149/mo. No membership, no hidden fees, free shipping.
Visit He & She MD →
Enhance MD
Injections or needle-free sublingual wafers. Physician oversight included.
Visit Enhance MD →| Feature | He & She MD | Enhance MD |
|---|---|---|
| Editorial score | 9.90 / 10 | 8.51 / 10 |
| Starting price | $149/mo (12-month supply) | Wafers $84/mo; injection $169/mo |
| Renewal / ongoing | Flat $149/mo across every format | Wafers $84–$99; injection $169–$199 |
| Delivery formats | Injection, topical cream & nasal spray | Injection + sublingual wafer |
| Dose strengths | Supplied as a 12-month course | Per physician protocol |
| Shipping | Free expedited | Included |
| Membership / fees | None — no membership cost | None |
| Guarantee | — | Refund if ineligible |
| Best for | People who want a choice of injection, cream, or nasal spray at one flat, transparent price with included ongoing care | People weighing injectable NAD+ against a needle-free sublingual wafer with full price transparency |
Where He & She MD stands out
- + Higher editorial score (9.90 vs 8.51)
Where Enhance MD stands out
- + Lower entry price — Wafers $84/mo; injection $169/mo
- + Backed by a refund if ineligible
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format
- + No membership cost and no hidden fees
- + Board-certified providers and FDA-regulated dispensing pharmacies
- + Unlimited provider messaging for ongoing care
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is tied to a 12-month supply commitment
Enhance MD
Pros
- + Needle-free sublingual wafer alternative to injections
- + Full published pricing matrix by commitment length
- + Provider check-ins and unlimited messaging included
- + Full refund if found ineligible
Cons
- − Lowest prices require a 12-month prepaid commitment
- − No nasal spray option
The verdict: He & She MD vs Enhance MD
In our editorial ranking, He & She MD places higher (#1 vs #15), making it the default pick for most readers — it's best for people who want a choice of injection, cream, or nasal spray at one flat, transparent price with included ongoing care. That said, Enhance MD is the stronger choice for people weighing injectable NAD+ against a needle-free sublingual wafer with full price transparency. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.