He & She MD vs Enhance MD: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while Enhance MD starts at wafers $84/mo; injection $169/mo with injection + sublingual wafer. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 32 Providers Compared
He & She MD
The only major NAD+ provider that lets you pick your format — injection, cream, or nasal spray — without paying a cent more for the privilege.
Visit He & She MD →
Enhance MD
Injections or needle-free sublingual wafers. Physician oversight included.
Visit Enhance MD →| Feature | He & She MD | Enhance MD |
|---|---|---|
| Editorial score | 9.92 / 10 | 8.80 / 10 |
| Starting price | $149/mo (12-month supply) | Wafers $84/mo; injection $169/mo |
| Renewal / ongoing | Flat $149/mo across every format | Wafers $84–$99; injection $169–$199 |
| Delivery formats | Injection, topical cream & nasal spray | Injection + sublingual wafer |
| Dose strengths | Supplied as a 12-month course | Per physician protocol |
| Shipping | Free expedited | Included |
| Membership / fees | None — no membership cost | None |
| Guarantee | — | Refund if ineligible |
| Best for | People who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost | People weighing injectable NAD+ against a needle-free sublingual wafer with full price transparency |
Where He & She MD stands out
- + Higher editorial score (9.92 vs 8.80)
Where Enhance MD stands out
- + Lower entry price — Wafers $84/mo; injection $169/mo
- + Backed by a refund if ineligible
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — subcutaneous injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format, locked on a 12-month supply
- + No membership fee, no hidden costs, and HSA/FSA cards accepted
- + 5-minute intake quiz reviewed by a licensed U.S. physician or DO
- + Unlimited provider messaging for as long as you are on the program
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is locked on a 12-month supply ($1,788/yr)
Enhance MD
Pros
- + Needle-free sublingual wafer alternative to injections
- + Full published pricing matrix by commitment length
- + Provider check-ins and unlimited messaging included
- + Full refund if found ineligible
Cons
- − Lowest prices require a 12-month prepaid commitment
- − No nasal spray option
The verdict: He & She MD vs Enhance MD
In our editorial ranking, He & She MD places higher (#1 vs #17), making it the default pick for most readers — it's best for people who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost. That said, Enhance MD is the stronger choice for people weighing injectable NAD+ against a needle-free sublingual wafer with full price transparency. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.