System vs Tmates: NAD+ Therapy Compared
System starts at injection $89 · nasal $69 (first month) and offers injection + nasal spray, while Tmates starts at $149/mo (as low as ~$88 on longer plans) with not disclosed. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 22 Providers Compared
- Results in 2–4 Weeks
System
NAD+ injections from $89 and nasal treatment from $69 for the first month. Injection and nasal pricing shown separately.
Visit System →
Tmates
NAD+ treatment from $149 for one month, as low as approximately $88 monthly on longer plans.
Visit Tmates →| Feature | System | Tmates |
|---|---|---|
| Editorial score | 8.70 / 10 | 8.60 / 10 |
| Starting price | Injection $89 · nasal $69 (first month) | $149/mo (as low as ~$88 on longer plans) |
| Renewal / ongoing | Shown during intake | From ~$88/mo on longer plans |
| Delivery formats | Injection + nasal spray | Not disclosed |
| Dose strengths | Not disclosed | Not disclosed |
| Shipping | Not stated | Not stated |
| Membership / fees | None | None |
| Guarantee | — | — |
| Best for | People choosing between injectable and nasal NAD+ with separate, accessible first-month pricing | People comfortable with a longer plan commitment to reach the lowest monthly NAD+ price |
Where System stands out
- + Lower entry price — Injection $89 · nasal $69 (first month)
- + More delivery formats — injection + nasal spray
- + Higher editorial score (8.70 vs 8.60)
Where Tmates stands out
Tmates is closely matched with System on the headline metrics — the deciding factors come down to delivery format and the specifics below.
Pros & cons, side by side
System
Pros
- + Both injection and nasal NAD+ options
- + Accessible first-month pricing
- + Fully online process
Cons
- − Compounded NAD+ — not an FDA-approved finished product
- − Ongoing pricing shown during intake
Tmates
Pros
- + Lower monthly cost on longer plans
- + HSA/FSA eligible
- + Fully online intake
Cons
- − Lowest price requires a longer commitment
- − Compounded NAD+ — not an FDA-approved finished product
The verdict: System vs Tmates
In our editorial ranking, System places higher (#18 vs #19), making it the default pick for most readers — it's best for people choosing between injectable and nasal NAD+ with separate, accessible first-month pricing. That said, Tmates is the stronger choice for people comfortable with a longer plan commitment to reach the lowest monthly NAD+ price. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.