DirectMeds vs He & She MD: NAD+ Therapy Compared
- Physician-prescribed only
- 31 providers compared
DirectMeds
DirectMeds delivers physician-prescribed NAD+ injections straight to your door, combining transparent all-inclusive pricing, fast US pharmacy fulfillment, and ongoing nursing support.
Visit DirectMeds →
He & She MD
The only major NAD+ provider that lets you pick your format, injection, cream, or nasal spray, without paying a cent more for the privilege.
Visit He & She MD →| Feature | DirectMeds | He & She MD |
|---|---|---|
| Editorial score | 9.86 / 10 | 9.28 / 10 |
| Starting price | $99 first month (500mg) | $149/mo (12-month supply) |
| Renewal / ongoing | $199 (500mg) / $249 (1000mg) | Flat $149/mo across every format |
| Delivery formats | Injection | Injection, topical cream & nasal spray |
| Dose strengths | 500mg & 1000mg | Supplied as a 12-month course |
| Shipping | Free 1–2 day | Free expedited |
| Membership / fees | None: no subscription | None: no membership cost |
| Guarantee | Satisfaction guarantee | - |
| Best for | People who want prescription-grade, physician-reviewed NAD+ with all-inclusive pricing, no insurance, and 1–2 day delivery | People who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost |
Where DirectMeds stands out
- + Lower entry price, $99 first month (500mg)
- + Backed by a satisfaction guarantee
- + Higher editorial score (9.86 vs 9.28)
Where He & She MD stands out
- + More delivery formats, injection, topical cream & nasal spray
Pros & cons, side by side
DirectMeds
Pros
- + $100 off first month on the 500mg plan, $99 to start, then $199/mo
- + One transparent monthly price covering medication, consultation, and shipping
- + No insurance required and no hidden fees
- + Medication compounded by FDA-registered US pharmacies
- + Provider review typically within a day, then 1–2 day shipping with full tracking
- + LegitScript certified, with over 180,000 customers served and a 4.6-star Trustpilot rating
Cons
- − Injection-only: no nasal or oral option
- − The 500mg plan renews at $199/mo after the discounted first month
- − 1000mg plan renews at $249/mo
He & She MD
Pros
- + Three delivery formats: subcutaneous injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format, locked on a 12-month supply
- + No membership fee, no hidden costs, and HSA/FSA cards accepted
- + 5-minute intake quiz reviewed by a licensed U.S. physician or DO
- + Unlimited provider messaging for as long as you are on the program
Cons
- − Compounded NAD+: not an FDA-approved finished drug product
- − The $149/mo rate is locked on a 12-month supply ($1,788/yr)
The verdict: DirectMeds vs He & She MD
In our editorial ranking, DirectMeds places higher (#3 vs #12), making it the default pick for most readers, it's best for people who want prescription-grade, physician-reviewed NAD+ with all-inclusive pricing, no insurance, and 1–2 day delivery. That said, He & She MD is the stronger choice for people who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change, always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.
Independent provider research and pricing analysis
Non-clinical editorial team, see our disclosure
This page is independent editorial research, not medical advice, and has not been reviewed by a licensed clinician. NAD+ requires evaluation by a licensed healthcare professional, and a prescription is not guaranteed. Discuss your health history, medications and treatment goals with a qualified clinician before starting any treatment.
Medical Disclaimer
The information on BestNADTreatments.com is provided for educational and comparison purposes only. It is not medical advice and does not replace consultation with a qualified healthcare professional. NAD+ treatment requires evaluation by a licensed clinician, and a prescription is not guaranteed. Compounded medications are not FDA-approved, and treatment availability varies by state and provider.
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