DirectMeds vs System: NAD+ Therapy Compared
DirectMeds starts at $99 first month (500mg) and offers injection, while System starts at injection $89 · nasal $69 (first month) with injection + nasal spray. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 22 Providers Compared
- Results in 2–4 Weeks
DirectMeds
Save $100 first month — 500mg from $99, then $199. 250,000+ served. No subscription.
Visit DirectMeds →System
NAD+ injections from $89 and nasal treatment from $69 for the first month. Injection and nasal pricing shown separately.
Visit System →| Feature | DirectMeds | System |
|---|---|---|
| Editorial score | 9.64 / 10 | 8.70 / 10 |
| Starting price | $99 first month (500mg) | Injection $89 · nasal $69 (first month) |
| Renewal / ongoing | $199 (500mg) / $249 (1000mg) | Shown during intake |
| Delivery formats | Injection | Injection + nasal spray |
| Dose strengths | 500mg & 1000mg | Not disclosed |
| Shipping | Free 1–2 day | Not stated |
| Membership / fees | None — no subscription | None |
| Guarantee | Satisfaction guarantee | — |
| Best for | People who want exact upfront pricing and no forced subscription, reordering on their own schedule | People choosing between injectable and nasal NAD+ with separate, accessible first-month pricing |
Where DirectMeds stands out
- + Backed by a satisfaction guarantee
- + Higher editorial score (9.64 vs 8.70)
Where System stands out
- + Lower entry price — Injection $89 · nasal $69 (first month)
- + More delivery formats — injection + nasal spray
Pros & cons, side by side
DirectMeds
Pros
- + $100 off first month on the 500mg plan
- + Exact pricing shown upfront for both 500mg and 1000mg
- + No forced subscription — reorder manually when you want
- + 1:1 medical support with provider review within 24 hours
- + Free 1–2 day shipping included
Cons
- − Injection-only — no nasal or oral option
- − 1000mg plan renews at $249/mo
System
Pros
- + Both injection and nasal NAD+ options
- + Accessible first-month pricing
- + Fully online process
Cons
- − Compounded NAD+ — not an FDA-approved finished product
- − Ongoing pricing shown during intake
The verdict: DirectMeds vs System
In our editorial ranking, DirectMeds places higher (#4 vs #18), making it the default pick for most readers — it's best for people who want exact upfront pricing and no forced subscription, reordering on their own schedule. That said, System is the stronger choice for people choosing between injectable and nasal NAD+ with separate, accessible first-month pricing. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.