DirectMeds vs Shed: NAD+ Therapy Compared
DirectMeds starts at $99 first month (500mg) and offers injection, while Shed starts at $144/mo nasal (20% off first month) with nasal spray, injection & oral tablets. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 32 Providers Compared
DirectMeds
DirectMeds delivers physician-prescribed NAD+ injections straight to your door, combining transparent all-inclusive pricing, fast US pharmacy fulfillment, and ongoing nursing support.
Visit DirectMeds →
Shed
Three NAD+ formats: nasal, injections, and oral. Coaching resources included.
Visit Shed →| Feature | DirectMeds | Shed |
|---|---|---|
| Editorial score | 9.78 / 10 | 9.00 / 10 |
| Starting price | $99 first month (500mg) | $144/mo nasal (20% off first month) |
| Renewal / ongoing | $199 (500mg) / $249 (1000mg) | $144 nasal / $169 injection & oral |
| Delivery formats | Injection | Nasal spray, injection & oral tablets |
| Dose strengths | 500mg & 1000mg | Provider-determined |
| Shipping | Free 1–2 day | To your door |
| Membership / fees | None — no subscription | None — 1:1 coaching is an optional add-on |
| Guarantee | Satisfaction guarantee | — |
| Best for | People who want prescription-grade, physician-reviewed NAD+ with all-inclusive pricing, no insurance, and 1–2 day delivery | People who want format choice plus built-in wellness coaching resources |
Where DirectMeds stands out
- + Lower entry price — $99 first month (500mg)
- + Backed by a satisfaction guarantee
- + Higher editorial score (9.78 vs 9.00)
Where Shed stands out
- + More delivery formats — nasal spray, injection & oral tablets
Pros & cons, side by side
DirectMeds
Pros
- + $100 off first month on the 500mg plan — $99 to start, then $199/mo
- + One transparent monthly price covering medication, consultation, and shipping
- + No insurance required and no hidden fees
- + Medication compounded by FDA-registered US pharmacies
- + Provider review typically within a day, then 1–2 day shipping with full tracking
- + LegitScript certified, with over 180,000 customers served and a 4.6-star Trustpilot rating
Cons
- − Injection-only — no nasal or oral option
- − The 500mg plan renews at $199/mo after the discounted first month
- − 1000mg plan renews at $249/mo
Shed
Pros
- + Three delivery formats: nasal spray, injection, and oral tablets
- + Health courses and community included
- + Strong 4.6-star Trustpilot rating
Cons
- − 1-on-1 coaching is a paid add-on
- − Cancellation requires completing at least two months
The verdict: DirectMeds vs Shed
In our editorial ranking, DirectMeds places higher (#6 vs #15), making it the default pick for most readers — it's best for people who want prescription-grade, physician-reviewed NAD+ with all-inclusive pricing, no insurance, and 1–2 day delivery. That said, Shed is the stronger choice for people who want format choice plus built-in wellness coaching resources. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.