DirectMeds vs Tmates: NAD+ Therapy Compared
DirectMeds starts at $99 first month (500mg) and offers injection, while Tmates starts at $149/mo (as low as ~$88 on longer plans) with not disclosed. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 22 Providers Compared
- Results in 2–4 Weeks
DirectMeds
Save $100 first month — 500mg from $99, then $199. 250,000+ served. No subscription.
Visit DirectMeds →
Tmates
NAD+ treatment from $149 for one month, as low as approximately $88 monthly on longer plans.
Visit Tmates →| Feature | DirectMeds | Tmates |
|---|---|---|
| Editorial score | 9.64 / 10 | 8.60 / 10 |
| Starting price | $99 first month (500mg) | $149/mo (as low as ~$88 on longer plans) |
| Renewal / ongoing | $199 (500mg) / $249 (1000mg) | From ~$88/mo on longer plans |
| Delivery formats | Injection | Not disclosed |
| Dose strengths | 500mg & 1000mg | Not disclosed |
| Shipping | Free 1–2 day | Not stated |
| Membership / fees | None — no subscription | None |
| Guarantee | Satisfaction guarantee | — |
| Best for | People who want exact upfront pricing and no forced subscription, reordering on their own schedule | People comfortable with a longer plan commitment to reach the lowest monthly NAD+ price |
Where DirectMeds stands out
- + Lower entry price — $99 first month (500mg)
- + Backed by a satisfaction guarantee
- + Higher editorial score (9.64 vs 8.60)
Where Tmates stands out
Tmates is closely matched with DirectMeds on the headline metrics — the deciding factors come down to delivery format and the specifics below.
Pros & cons, side by side
DirectMeds
Pros
- + $100 off first month on the 500mg plan
- + Exact pricing shown upfront for both 500mg and 1000mg
- + No forced subscription — reorder manually when you want
- + 1:1 medical support with provider review within 24 hours
- + Free 1–2 day shipping included
Cons
- − Injection-only — no nasal or oral option
- − 1000mg plan renews at $249/mo
Tmates
Pros
- + Lower monthly cost on longer plans
- + HSA/FSA eligible
- + Fully online intake
Cons
- − Lowest price requires a longer commitment
- − Compounded NAD+ — not an FDA-approved finished product
The verdict: DirectMeds vs Tmates
In our editorial ranking, DirectMeds places higher (#4 vs #19), making it the default pick for most readers — it's best for people who want exact upfront pricing and no forced subscription, reordering on their own schedule. That said, Tmates is the stronger choice for people comfortable with a longer plan commitment to reach the lowest monthly NAD+ price. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.