He & She MD vs Eden: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while Eden starts at $119 first month (~$15/shot) with injection (+ separate nasal spray). Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 32 Providers Compared
He & She MD
The only major NAD+ provider that lets you pick your format — injection, cream, or nasal spray — without paying a cent more for the privilege.
Visit He & She MD →
Eden
NAD+ from $119 first month (~$15/shot). FSA/HSA eligible. Klarna & Afterpay available.
Visit Eden →| Feature | He & She MD | Eden |
|---|---|---|
| Editorial score | 9.92 / 10 | 8.70 / 10 |
| Starting price | $149/mo (12-month supply) | $119 first month (~$15/shot) |
| Renewal / ongoing | Flat $149/mo across every format | Medication + $99/mo membership |
| Delivery formats | Injection, topical cream & nasal spray | Injection (+ separate nasal spray) |
| Dose strengths | Supplied as a 12-month course | 500–1000mg at 200mg/mL |
| Shipping | Free expedited | Free 2-day + home kit |
| Membership / fees | None — no membership cost | $39 then $99/mo (required) |
| Guarantee | — | — |
| Best for | People who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost | People who want flexible financing and FSA/HSA payment for physician-supervised NAD+ |
Where He & She MD stands out
- + No required membership fee
- + Higher editorial score (9.92 vs 8.70)
Where Eden stands out
- + Lower entry price — $119 first month (~$15/shot)
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — subcutaneous injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format, locked on a 12-month supply
- + No membership fee, no hidden costs, and HSA/FSA cards accepted
- + 5-minute intake quiz reviewed by a licensed U.S. physician or DO
- + Unlimited provider messaging for as long as you are on the program
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is locked on a 12-month supply ($1,788/yr)
Eden
Pros
- + Low ~$15-per-shot framing with free 2-day shipping and home kit
- + FSA/HSA eligible
- + Pay over time with Klarna or Afterpay
- + 500–1000mg injections plus a separate nasal spray option
Cons
- − Requires an Eden membership ($39 first month, then $99/mo) on top of medication
- − Compounded NAD+ — not an FDA-approved finished product
The verdict: He & She MD vs Eden
In our editorial ranking, He & She MD places higher (#1 vs #18), making it the default pick for most readers — it's best for people who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost. That said, Eden is the stronger choice for people who want flexible financing and FSA/HSA payment for physician-supervised NAD+. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.