He & She MD vs Fridays: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while Fridays starts at $179/mo (billed quarterly) with injection, nasal spray & oral liposomal. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 22 Providers Compared
- Results in 2–4 Weeks
He & She MD
Our #1 NAD+ pick — three formats (injection, cream, and nasal spray) at one flat $149/mo. No membership, no hidden fees, free shipping.
Visit He & She MD →
Fridays
NAD+ from $179/mo (billed quarterly). Injection, nasal spray, or oral liposomal.
Visit Fridays →| Feature | He & She MD | Fridays |
|---|---|---|
| Editorial score | 9.90 / 10 | 9.43 / 10 |
| Starting price | $149/mo (12-month supply) | $179/mo (billed quarterly) |
| Renewal / ongoing | Flat $149/mo across every format | Nasal & oral $229/mo |
| Delivery formats | Injection, topical cream & nasal spray | Injection, nasal spray & oral liposomal |
| Dose strengths | Supplied as a 12-month course | Oral 50/100/150mg daily; injection 3×/week |
| Shipping | Free expedited | Medication included |
| Membership / fees | None — no membership cost | None |
| Guarantee | — | — |
| Best for | People who want a choice of injection, cream, or nasal spray at one flat, transparent price with included ongoing care | People wanting personalized NAD+ with a choice of injection, nasal spray, or oral delivery |
Where He & She MD stands out
- + Lower entry price — $149/mo (12-month supply)
- + Higher editorial score (9.90 vs 9.43)
Where Fridays stands out
- + More delivery formats — injection, nasal spray & oral liposomal
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format
- + No membership cost and no hidden fees
- + Board-certified providers and FDA-regulated dispensing pharmacies
- + Unlimited provider messaging for ongoing care
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is tied to a 12-month supply commitment
Fridays
Pros
- + One of the few providers offering injection, nasal spray, AND oral liposomal NAD+
- + Personalized protocol for your goals
- + Established trusted brand
Cons
- − Billed quarterly rather than month-to-month
- − Not available in all states
The verdict: He & She MD vs Fridays
In our editorial ranking, He & She MD places higher (#1 vs #11), making it the default pick for most readers — it's best for people who want a choice of injection, cream, or nasal spray at one flat, transparent price with included ongoing care. That said, Fridays is the stronger choice for people wanting personalized NAD+ with a choice of injection, nasal spray, or oral delivery. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.