He & She MD vs Fridays: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while Fridays starts at $179/mo (billed quarterly) with injection, nasal spray & oral liposomal. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 32 Providers Compared
He & She MD
The only major NAD+ provider that lets you pick your format — injection, cream, or nasal spray — without paying a cent more for the privilege.
Visit He & She MD →
Fridays
NAD+ from $179/mo (billed quarterly). Injection, nasal spray, or oral liposomal.
Visit Fridays →| Feature | He & She MD | Fridays |
|---|---|---|
| Editorial score | 9.92 / 10 | 9.15 / 10 |
| Starting price | $149/mo (12-month supply) | $179/mo (billed quarterly) |
| Renewal / ongoing | Flat $149/mo across every format | Nasal & oral $229/mo |
| Delivery formats | Injection, topical cream & nasal spray | Injection, nasal spray & oral liposomal |
| Dose strengths | Supplied as a 12-month course | Oral 50/100/150mg daily; injection 3×/week |
| Shipping | Free expedited | Medication included |
| Membership / fees | None — no membership cost | None |
| Guarantee | — | — |
| Best for | People who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost | People wanting personalized NAD+ with a choice of injection, nasal spray, or oral delivery |
Where He & She MD stands out
- + Lower entry price — $149/mo (12-month supply)
- + Higher editorial score (9.92 vs 9.15)
Where Fridays stands out
- + More delivery formats — injection, nasal spray & oral liposomal
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — subcutaneous injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format, locked on a 12-month supply
- + No membership fee, no hidden costs, and HSA/FSA cards accepted
- + 5-minute intake quiz reviewed by a licensed U.S. physician or DO
- + Unlimited provider messaging for as long as you are on the program
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is locked on a 12-month supply ($1,788/yr)
Fridays
Pros
- + One of the few providers offering injection, nasal spray, AND oral liposomal NAD+
- + Personalized protocol for your goals
- + Established trusted brand
Cons
- − Billed quarterly rather than month-to-month
- − Not available in all states
The verdict: He & She MD vs Fridays
In our editorial ranking, He & She MD places higher (#1 vs #13), making it the default pick for most readers — it's best for people who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost. That said, Fridays is the stronger choice for people wanting personalized NAD+ with a choice of injection, nasal spray, or oral delivery. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.