He & She MD vs RenuviaRX: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while RenuviaRX starts at $179 to start with injection. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 32 Providers Compared
He & She MD
The only major NAD+ provider that lets you pick your format — injection, cream, or nasal spray — without paying a cent more for the privilege.
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| Feature | He & She MD | RenuviaRX |
|---|---|---|
| Editorial score | 9.92 / 10 | 9.25 / 10 |
| Starting price | $149/mo (12-month supply) | $179 to start |
| Renewal / ongoing | Flat $149/mo across every format | $249/mo |
| Delivery formats | Injection, topical cream & nasal spray | Injection |
| Dose strengths | Supplied as a 12-month course | Per physician protocol |
| Shipping | Free expedited | Free |
| Membership / fees | None — no membership cost | None |
| Guarantee | — | — |
| Best for | People who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost | People who want a board-certified physician to design their NAD+ protocol for both anti-aging skin benefits and improved energy and mental clarity. |
Where He & She MD stands out
- + Lower entry price — $149/mo (12-month supply)
- + More delivery formats — injection, topical cream & nasal spray
- + Higher editorial score (9.92 vs 9.25)
Where RenuviaRX stands out
RenuviaRX is closely matched with He & She MD on the headline metrics — the deciding factors come down to delivery format and the specifics below.
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — subcutaneous injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format, locked on a 12-month supply
- + No membership fee, no hidden costs, and HSA/FSA cards accepted
- + 5-minute intake quiz reviewed by a licensed U.S. physician or DO
- + Unlimited provider messaging for as long as you are on the program
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is locked on a 12-month supply ($1,788/yr)
RenuviaRX
Pros
- + Board-certified physicians customize every treatment plan
- + Targets cellular skin repair alongside energy and mental clarity
- + No insurance needed — straightforward $179 starting price
- + Free shipping included on every order
- + Comprehensive approach: look younger and feel younger
Cons
- − Newer platform with a smaller patient base than legacy providers
- − Injection-only — no nasal or oral option
The verdict: He & She MD vs RenuviaRX
In our editorial ranking, He & She MD places higher (#1 vs #12), making it the default pick for most readers — it's best for people who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost. That said, RenuviaRX is the stronger choice for people who want a board-certified physician to design their NAD+ protocol for both anti-aging skin benefits and improved energy and mental clarity.. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.