He & She MD vs RXSpan: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while RXSpan starts at ~$249 (recurring) with not disclosed. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 32 Providers Compared
He & She MD
The only major NAD+ provider that lets you pick your format — injection, cream, or nasal spray — without paying a cent more for the privilege.
Visit He & She MD →
RXSpan
NAD+ treatment starting at approximately $249. Online medical consultation included; recurring billing shown before checkout.
Visit RXSpan →| Feature | He & She MD | RXSpan |
|---|---|---|
| Editorial score | 9.92 / 10 | 7.90 / 10 |
| Starting price | $149/mo (12-month supply) | ~$249 (recurring) |
| Renewal / ongoing | Flat $149/mo across every format | Recurring; shown before checkout |
| Delivery formats | Injection, topical cream & nasal spray | Not disclosed |
| Dose strengths | Supplied as a 12-month course | Not disclosed |
| Shipping | Free expedited | Not stated |
| Membership / fees | None — no membership cost | None |
| Guarantee | — | — |
| Best for | People who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost | People who want a physician-consulted NAD+ plan with clear recurring billing before checkout |
Where He & She MD stands out
- + Lower entry price — $149/mo (12-month supply)
- + More delivery formats — injection, topical cream & nasal spray
- + Higher editorial score (9.92 vs 7.90)
Where RXSpan stands out
RXSpan is closely matched with He & She MD on the headline metrics — the deciding factors come down to delivery format and the specifics below.
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — subcutaneous injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format, locked on a 12-month supply
- + No membership fee, no hidden costs, and HSA/FSA cards accepted
- + 5-minute intake quiz reviewed by a licensed U.S. physician or DO
- + Unlimited provider messaging for as long as you are on the program
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is locked on a 12-month supply ($1,788/yr)
RXSpan
Pros
- + Online medical consultation included
- + Recurring billing shown before checkout
- + Fully online process
Cons
- − Higher starting price than many competitors
- − Compounded NAD+ — not an FDA-approved finished product
The verdict: He & She MD vs RXSpan
In our editorial ranking, He & She MD places higher (#1 vs #26), making it the default pick for most readers — it's best for people who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost. That said, RXSpan is the stronger choice for people who want a physician-consulted NAD+ plan with clear recurring billing before checkout. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.