He & She MD vs RXSpan: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while RXSpan starts at ~$249 (recurring) with not disclosed. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 22 Providers Compared
- Results in 2–4 Weeks
He & She MD
Our #1 NAD+ pick — three formats (injection, cream, and nasal spray) at one flat $149/mo. No membership, no hidden fees, free shipping.
Visit He & She MD →RXSpan
NAD+ treatment starting at approximately $249. Online medical consultation included; recurring billing shown before checkout.
Visit RXSpan →| Feature | He & She MD | RXSpan |
|---|---|---|
| Editorial score | 9.90 / 10 | 8.40 / 10 |
| Starting price | $149/mo (12-month supply) | ~$249 (recurring) |
| Renewal / ongoing | Flat $149/mo across every format | Recurring; shown before checkout |
| Delivery formats | Injection, topical cream & nasal spray | Not disclosed |
| Dose strengths | Supplied as a 12-month course | Not disclosed |
| Shipping | Free expedited | Not stated |
| Membership / fees | None — no membership cost | None |
| Guarantee | — | — |
| Best for | People who want a choice of injection, cream, or nasal spray at one flat, transparent price with included ongoing care | People who want a physician-consulted NAD+ plan with clear recurring billing before checkout |
Where He & She MD stands out
- + Lower entry price — $149/mo (12-month supply)
- + More delivery formats — injection, topical cream & nasal spray
- + Higher editorial score (9.90 vs 8.40)
Where RXSpan stands out
RXSpan is closely matched with He & She MD on the headline metrics — the deciding factors come down to delivery format and the specifics below.
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format
- + No membership cost and no hidden fees
- + Board-certified providers and FDA-regulated dispensing pharmacies
- + Unlimited provider messaging for ongoing care
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is tied to a 12-month supply commitment
RXSpan
Pros
- + Online medical consultation included
- + Recurring billing shown before checkout
- + Fully online process
Cons
- − Higher starting price than many competitors
- − Compounded NAD+ — not an FDA-approved finished product
The verdict: He & She MD vs RXSpan
In our editorial ranking, He & She MD places higher (#1 vs #21), making it the default pick for most readers — it's best for people who want a choice of injection, cream, or nasal spray at one flat, transparent price with included ongoing care. That said, RXSpan is the stronger choice for people who want a physician-consulted NAD+ plan with clear recurring billing before checkout. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.