He & She MD vs Shed: NAD+ Therapy Compared
He & She MD starts at $149/mo (12-month supply) and offers injection, topical cream & nasal spray, while Shed starts at $144/mo nasal (20% off first month) with nasal spray, injection & oral tablets. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
- Physician-Prescribed Only
- 32 Providers Compared
He & She MD
The only major NAD+ provider that lets you pick your format — injection, cream, or nasal spray — without paying a cent more for the privilege.
Visit He & She MD →
Shed
Three NAD+ formats: nasal, injections, and oral. Coaching resources included.
Visit Shed →| Feature | He & She MD | Shed |
|---|---|---|
| Editorial score | 9.92 / 10 | 9.00 / 10 |
| Starting price | $149/mo (12-month supply) | $144/mo nasal (20% off first month) |
| Renewal / ongoing | Flat $149/mo across every format | $144 nasal / $169 injection & oral |
| Delivery formats | Injection, topical cream & nasal spray | Nasal spray, injection & oral tablets |
| Dose strengths | Supplied as a 12-month course | Provider-determined |
| Shipping | Free expedited | To your door |
| Membership / fees | None — no membership cost | None — 1:1 coaching is an optional add-on |
| Guarantee | — | — |
| Best for | People who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost | People who want format choice plus built-in wellness coaching resources |
Where He & She MD stands out
- + Higher editorial score (9.92 vs 9.00)
Where Shed stands out
- + Lower entry price — $144/mo nasal (20% off first month)
- + More delivery formats — nasal spray, injection & oral tablets
Pros & cons, side by side
He & She MD
Pros
- + Three delivery formats — subcutaneous injection, topical cream, and nasal spray
- + Two needle-free options (cream and nasal spray), rare in this market
- + One flat $149/mo price across every format, locked on a 12-month supply
- + No membership fee, no hidden costs, and HSA/FSA cards accepted
- + 5-minute intake quiz reviewed by a licensed U.S. physician or DO
- + Unlimited provider messaging for as long as you are on the program
Cons
- − Compounded NAD+ — not an FDA-approved finished drug product
- − The $149/mo rate is locked on a 12-month supply ($1,788/yr)
Shed
Pros
- + Three delivery formats: nasal spray, injection, and oral tablets
- + Health courses and community included
- + Strong 4.6-star Trustpilot rating
Cons
- − 1-on-1 coaching is a paid add-on
- − Cancellation requires completing at least two months
The verdict: He & She MD vs Shed
In our editorial ranking, He & She MD places higher (#1 vs #15), making it the default pick for most readers — it's best for people who want injection, cream, or nasal spray at one identical price, so the decision is about comfort rather than cost. That said, Shed is the stronger choice for people who want format choice plus built-in wellness coaching resources. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.